Uncovering the Biology Behind Programmed Cell Death 1 (PD-1)
Ligation of the antigen receptors is insufficient to fully activate T cells, and additional signals must be provided by co-receptors. Understanding the biology behind these co-receptors is essential, due to their status as an ideal target in therapies. However, our mechanistic understanding of the signaling pathways downstream of T cell co-receptors is as of yet inadequate for this purpose.
![A summary of all the proteins that we discovered to regulate PD-1 signaling and function.](https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_200/public/media/images/2021-12/signaling.jpg?itok=nmGKGoJV 200w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_260/public/media/images/2021-12/signaling.jpg?itok=EHWb6whP 260w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_320/public/media/images/2021-12/signaling.jpg?itok=9wlgJSvs 320w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_400/public/media/images/2021-12/signaling.jpg?itok=_vyJyLFQ 400w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_520/public/media/images/2021-12/signaling.jpg?itok=5yif10zJ 520w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_640/public/media/images/2021-12/signaling.jpg?itok=c5dJGKui 640w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_800/public/media/images/2021-12/signaling.jpg?itok=woesaRlM 800w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_1040/public/media/images/2021-12/signaling.jpg?itok=GTswCDEH 1040w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_1600/public/media/images/2021-12/signaling.jpg?itok=xQALC-d7 1200w, https://www.rheumatologyatcolumbia.org/sites/default/files/styles/cola_media_1280/public/media/images/2021-12/signaling.jpg?itok=36KKDcZc 1280w)
A summary of all the proteins that we discovered to regulate PD-1 signaling and function.
Using cell biology and genetic approaches, we have uncovered the signaling pathways at work downstream of CD28 and CTLA-4, within the context of diverse cellular functions. One of our lab’s major ongoing research projects is uncovering the biology of PD-1 and LAG3 in exhausted T cells.