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One of our lab’s major ongoing research projects is uncovering the biology of PD-1 and LAG3 in exhausted T cells.
Using high-resolution proteomic approaches, we have uncovered targetable signaling proteins downstream of PD-1 as well as novel checkpoints that are highly expressed on tumor-infiltrating lymphocytes.
We study the ways in which PD-1 blockade reshape homeostatic T cell responses, making use of single-cell RNA sequencing.
Our work includes a functional inhibitory RNA screen to identify signaling mediators downstream of CXCR4 within human T cells and discovering a novel role for PLCe1 in recruitment of T cells.