Target T Cell Adhesion and Migration in Autoimmunity
The adhesion of T cells, and their migration into inflammatory organs, is a targeted process in the treatment of patients suffering from autoimmunity. Proper immune system function depends on directing the traffic of T cells throughout the body. Chemokines guide leukocyte homing and play a fundamental role in cellular recruitment towards the sites of inflammation.
We have already completed a functional inhibitory RNA screen to identify signaling mediators downstream of CXCR4 within human T cells, and we have discovered a novel role for the enzyme PLCe1 in the recruitment of T cells to inflamed organs, uncovering the underlying mechanism at work. We are currently expanding these studies in order to better understand the factors leading to the recruitment and retention of auto-reactive T cells in inflamed tissues.